The Boston College football team (begun in 1892) played its first game at Fenway Park in 1914 and in fact played their home games at Fenway for 13 different seasons, the first in 1928, the last being 1953-1956. Just like Boston University, they too found Fenway to their liking, going 56-16-1 in the 13 seasons they called Fenway Park home. In the other 10 seasons when they played at least a game at Fenway, they enjoyed success as well, going 11-5-3. Their overall mark of 67-21-4 is an indicator of just how much the Eagles liked keeping their nest at Fenway. In the days when they played their home games in other venues, they often played their traditional rivalry game with Holy Cross at Fenway Park; simply because it was big enough to hold the crowd which often broached 40,000. In 1940, 41 and 42 Boston College was a national power and in that stretch they were an astounding 20-2 at Fenway Park. One of those losses came at the hands of their rival Holy Cross.
It was November 28, 1942 when the the Eagles took the field at Fenway. Undefeated and ranked number one in the nation, they were a three touchdown favorite to beat the Crusaders and claim their first National Championship. Led by their All American fullback Mike Holovak (who would coach the Boston Patriots from 1963-69) the Eagles were so sure of victory they booked the popular Boston nightclub, the Cocoanut Grove for their Saturday night championship celebration. Holy Cross, however, had other ideas and not only did they beat the Eagles, they trounced them 55-12; canceling the season and the victory party. As the would be champions left Fenway Park on that cold November afternoon, mired as they were in disappointment, they could not have known just how much they had won. For that night, the Cocoanut Grove burned to the ground and nearly 500 people lost their lives in what remains today, the second largest nightclub fire in the history of the United States.